ODCs

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1 OMIM reference -
1 associated gene
27 signs/symptoms

PROTEIN INTERACTIONS: 1

16 OMIM references -
4 associated genes
No signs/symptoms info

Acute intermittent porphyria

Early-onset autosomal dominant Alzheimer disease


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	HMBS	(0.56)	APP

Citations in the biomedical literature:

Acute intermittent porphyria		Early-onset autosomal dominant Alzheimer disease
	Synonym(s): (no synonyms)		Synonym(s): - EOFAD - Early-onset familial autosomal dominant Alzheimer disease - Familial Alzheimer disease

	Classification (Orphanet): - Inborn errors of metabolism - Rare eye disease - Rare genetic disease - Rare renal disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adolescence / young Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: adult Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: D017118		External references: 16 OMIM references - No MeSH references

Acute intermittent porphyria
	Very frequent - Abnormal colour of the urine / cholic / dark urines - Acute abdominal pain / colic - Anorexia - Humour troubles / anxiety / depression / apathy / euphoria / irritability - Insomnia - Muscle weakness / flaccidity - Myalgia / muscular pain - Nausea / vomiting / regurgitation / merycism / hyperemesis - Pollakiuria / polyuria / dysuria / anuria / acute urine retention / oliguria - Psychic / behavioural troubles - Seizures / epilepsy / absences / spasms / status epilepticus Frequent - Acute arterial hypertension / hypertensive crisis - Cardiac rhythm disorder / arrhythmia - Constipation - Hyperhidrosis / increased sweating - Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness Occasional - Articular / joint pain / arthralgia - Cranial nerves palsy - Delirium / hallucination - Diaphragmatic palsy - Hemiplegia / diplegia / hemiparesia / limb palsy - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Hyperlipidemia / hypercholesterolemia / hypertriglyceridemia - Hyponatremia - Obnubilation / coma / lethargia / desorientation - Renal failure - Weight loss / loss of appetite / break in weight curve / general health alteration
Early-onset autosomal dominant Alzheimer disease
(no data available)